ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9.

  title={ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9.},
  author={Eric C Logue and Sonia Bakkour and Michael L M Murphy and Hector Nolla and William C. Sha},
  journal={Journal of immunology},
  volume={177 4},
We report in this study that B7h, the ligand for the ICOS costimulatory receptor, is rapidly shed from mouse B cells following either ICOS binding or BCR engagement. Shedding occurs through proteolytic cleavage that releases the extracellular ICOS-binding region of B7h. Prior exposure of B7h-expressing APCs to ICOS-expressing cells inhibits their subsequent ability to costimulate IFN-gamma and IL-4 production from CD4+ T cells. Shedding is regulated as TLR7/8 and TLR9 ligands inhibit B7h… CONTINUE READING

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