ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

  title={ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity},
  author={Jared M. Odegard and Benjamin R. Marks and Leah D. DiPlacido and Amanda C. Poholek and Dwight H. Kono and Chen Dong and Richard A Flavell and Joseph E Craft},
  journal={The Journal of Experimental Medicine},
  pages={2873 - 2886}
The role of specialized follicular helper T (T(FH)) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr) (MRL(lpr)) mouse model of lupus. MRL(lpr) mice lacking the Icos gene have impaired extrafollicular differentiation of immunoglobulin (Ig) G(+) plasma cells accompanied by defects in CXC chemokine receptor… CONTINUE READING
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Odegard during the revision of this manuscript. We are grateful to M. Shlomchik for providing the anti-IgM antibody, V

  • J.M.A. Rudensky for supporting
  • Odegard and D. Schatz for the aicda probe and PCR…
  • 2008

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