ICOS Co-Stimulation: Friend or Foe?

  title={ICOS Co-Stimulation: Friend or Foe?},
  author={Daniel J. Wikenheiser and Jason S. Stumhofer},
  booktitle={Front. Immunol.},
Over the last 15 years, the inducible T cell co-stimulator (ICOS) has been implicated in various immune outcomes, including the induction and regulation of Th1, Th2, and Th17 immunity. In addition to its role in directing effector T cell differentiation, ICOS has also been consistently linked with the induction of thymus-dependent (TD) antibody (Ab) responses and the germinal center (GC) reaction. ICOS co-stimulation, therefore, appears to play a complex role in dictating the course of adaptive… CONTINUE READING
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