ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.

@article{Chaya2014ICKIE,
  title={ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.},
  author={Taro Chaya and Yoshihiro Omori and Ryusuke Kuwahara and Takahisa Furukawa},
  journal={The EMBO journal},
  year={2014},
  volume={33 11},
  pages={1227-42}
}
Cilia and flagella are formed and maintained by intraflagellar transport (IFT) and play important roles in sensing and moving across species. At the distal tip of the cilia/flagella, IFT complexes turn around to switch from anterograde to retrograde transport; however, the underlying regulatory mechanism is unclear. Here, we identified ICK localization at the tip of cilia as a regulator of ciliary transport. In ICK-deficient mice, we found ciliary defects in neuronal progenitor cells with… CONTINUE READING

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