ICI 182,780 inhibits endogenous estrogen-dependent rat uterine growth and tamoxifen-induced developmental toxicity.

@article{Branham1996ICI1I,
  title={ICI 182,780 inhibits endogenous estrogen-dependent rat uterine growth and tamoxifen-induced developmental toxicity.},
  author={William S. Branham and R B Fishman and Randal D Streck and K. L. Medlock and J J De George and Daniel M. Sheehan},
  journal={Biology of reproduction},
  year={1996},
  volume={54 1},
  pages={160-7}
}
To assess the effects of the steroidal antiestrogen ICI 182,780 on postnatal uterine development, female Sprague-Dawley rats were given s.c. injections of ICI 182,780 (0.1-100 micrograms/rat) on each of postnatal days (PND) 10-14. ICI 182,780 inhibited uterine growth, as measured by uterine weight, in a dose-dependent manner but had no effect on either… CONTINUE READING