ICI 182,780, a new antioestrogen with clinical potential.

  title={ICI 182,780, a new antioestrogen with clinical potential.},
  author={Alan E. Wakeling and Jeff Bowler},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={43 1-3},
Previous studies in this laboratory identified a series of 7 alpha-alkylamide analogues of 17 beta-oestradiol which are pure antioestrogens. Among this initial lead series of compounds, exemplified by ICI 164,384, none was of sufficient in vivo potency to merit serious consideration as a candidate for clinical evaluation. Further structure-activity studies identified a new compound, ICI 182,780, 7 alpha-[9-(4,4,5,5,5-pentafluoro-pentylsulphinyl)nonyl]oestra-1,3,5(10)- triene-3,17 beta-diol… CONTINUE READING