ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death

  title={ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death},
  author={Katerina Chlichlia and Meinrad Busslinger and Marcus E Peter and Henning Walczak and Peter Heinrich Krammer and Volker Schirrmacher and Khashayarsha Khazaie},
The Tax protein of Human T-cell leukemia virus type 1 (HTLV-1) is important for the T-cell immortalizing properties of this virus in vitro and is considered to be responsible for the early stages of leukemogenesis in infected hosts. Tax can upregulate expression of TNF-α and TNF-β, as well as potentiate apoptosis in activated T-cells and in serum starved… CONTINUE READING