ICE/CED-3 proteasesin apoptosis.

  title={ICE/CED-3 proteasesin apoptosis.},
  author={Moira K B Whyte},
  journal={Trends in cell biology},
  volume={6 7},
An expanding family of cysteine proteases, of which interleukin-1beta-converting enzyme (ICE) is the prototype, has been shown to play a key role in mammalian cell apoptosis. ICE is both a structural and functional homologue of the nematode 'death gene' ced-3. Here, Moira Whyte discusses how functional characterization of these ICE-like proteases and identification of their substrates is helping to elucidate the biochemical processes underlying the stereotyped morphology of apoptosis and to… CONTINUE READING

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