ICCVAM evaluation of the murine local lymph node assay. Data analyses completed by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.

@article{Haneke2001ICCVAMEO,
  title={ICCVAM evaluation of the murine local lymph node assay. Data analyses completed by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.},
  author={Karen Haneke and Raymond R. Tice and Bernadette L. Carson and Barry H. Margolin and William S. Stokes},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2001},
  volume={34 3},
  pages={
          274-86
        }
}
To evaluate the reliability of the murine local lymph node assay (LLNA), a test for allergic contact dermatitis activity, the inter- and intralaboratory consistency statistics (h and k, respectively) were calculated for validation studies testing multiple chemicals. The analysis indicated the absence of excessive variability in the dose calculated to induce a threefold or greater increase in the stimulation index (SI). To assess the appropriateness of using an SI of 3 as the decision criteria… CONTINUE READING

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