ICAM-1 supports adhesion of human small-cell lung carcinoma to endothelial cells

Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial step in metastasis, which is largely responsible for the poor prognosis of small-cell lung carcinoma (SCLC). Patients with SCLC were reported to have elevated levels of intercellular adhesion molecule-1 (ICAM-1). The present study therefore focuses on endothelial ICAM-1… CONTINUE READING