ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming.

  title={ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming.},
  author={Elodie Segura and Carole Nicco and B{\'e}rang{\`e}re Lombard and Philippe Véron and Graça Raposo and Fr{\'e}d{\'e}ric Batteux and S{\'e}bastian Amigorena and Clotilde Th{\'e}ry},
  volume={106 1},
Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes, which transfer functional major histocompatibility complex (MHC)-peptide complexes to other DCs. Since immature and mature DCs induce different functional T-cell responses (ie, tolerance versus priming), we asked whether DC maturation also influenced the priming abilities of their exosomes. We show that exosomes secreted by lipopolysaccharide (LPS)-treated mature DCs are 50- to… 

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