ICAM-1 directs migration and localization of interstitial leukocytes in experimental glomerulonephritis.

@article{Hill1994ICAM1DM,
  title={ICAM-1 directs migration and localization of interstitial leukocytes in experimental glomerulonephritis.},
  author={Prudence A. Hill and Han Y. Lan and David J Nikolic-Paterson and Robert C. Atkins},
  journal={Kidney international},
  year={1994},
  volume={45 1},
  pages={32-42}
}
Recent studies of rat anti-GBM disease have demonstrated a functional role of the ICAM-1/LFA-1 interaction in the entry of leukocytes into the glomerulus and an association between interstitial ICAM-1 expression, leukocyte infiltration and tubulointerstitial damage. In the current study, we used immunogold ultrastructural techniques to identify ICAM-1/LFA-1 interactions in the initiation of interstitial leukocyte infiltration during the first 24 hours of rat accelerated anti-GBM disease. In… CONTINUE READING