ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia.

Abstract

We examined brain sections from ICAM-1 deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) for the presence of apoptosis. Despite the reduction in necrosis, the -/- mice had apoptotic cells in the ischemic hemisphere as shown by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end… (More)

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@article{Soriano1998ICAM1DP, title={ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia.}, author={Sulpicio G. Soriano and Y Wang and Stuart A. Lipton and Pieter Dikkes and J-C Gutierrez-Ramos and Paul R. Hickey}, journal={Brain research}, year={1998}, volume={780 2}, pages={337-41} }