ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion.

@article{EtienneManneville1999ICAM1coupledSP,
  title={ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion.},
  author={Sandrine Etienne-Manneville and Nathalie Chaverot and Arthur Donny Strosberg and Pierre Olivier Couraud},
  journal={Journal of immunology},
  year={1999},
  volume={163 2},
  pages={668-74}
}
In the CNS, astrocytes play a key role in immunological and inflammatory responses through ICAM-1 expression, cytokine secretion (including TNF-alpha), and regulation of blood-brain barrier permeability. Because ICAM-1 transduces intracellular signals in lymphocytes and endothelial cells, we investigated in the present study ICAM-1-coupled signaling pathways in astrocytes. Using rat astrocytes in culture, we report that ICAM-1 binding by specific Abs induces TNF-alpha secretion together with… CONTINUE READING