ICAM-1 co-stimulates target cells to facilitate antigen presentation.

  title={ICAM-1 co-stimulates target cells to facilitate antigen presentation.},
  author={Tatiana Lebedeva and Michael L. Dustin and Yuri Sykulev},
  journal={Current opinion in immunology},
  volume={17 3},
Adhesion molecules are known to mediate cell-cell interactions, particularly those between T cells and antigen-presenting or target cells. Recent studies identified ICAM-1 as a co-stimulatory ligand that binds to lymphocyte function associated antigen-1 (LFA-1), thereby promoting the activation of T cells. As ICAM-1 is expressed on virtually any cell, it becomes a crucial molecule for the activation of CD8(+) T cells in the absence of co-stimulation provided by CD80 and CD86 molecules. In… CONTINUE READING