ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells.

@article{Rauch2007ICAM1AP,
  title={ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells.},
  author={Bernhard H Rauch and Birgit M{\"u}schenborn and Marina Braun and A A Weber and Karsten Schroer},
  journal={European journal of pharmacology},
  year={2007},
  volume={577 1-3},
  pages={
          54-7
        }
}
Fibrinogen deposition in the vessel wall represents an independent atherogenic risk factor. In Boyden-chamber assays, fibrinogen concentration-dependently (1-100 microM) induced migration of human vascular smooth muscle cells (SMC). This was inhibited by antibodies to intercellular adhesion molecule-1 (ICAM-1, 10 microg/ml), and by inhibitors of PI3-kinase (LY294002, 10 microM) and MAPK (mitogen-activated protein kinase) p38 (SB203580, 10 microM). The MEK (MAP kinase kinase) inhibitor PD98059… CONTINUE READING

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