ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic.

@article{dAlessio1998ICAM1AV,
  title={ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic.},
  author={Patrizia d'Alessio and Monique Moutet and Evelyne Coudrier and S Darquenne and J Chaudi{\`e}re},
  journal={Free radical biology & medicine},
  year={1998},
  volume={24 6},
  pages={979-87}
}
Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are respectively involved in the endothelial recruitment of neutrophils, and in that of lymphocytes or tumor cells, in response to specific signals. We have used the glutathione peroxidase (GPx) mimic BXT-51072 to assess the possibility that endogenous hydroperoxides play a role in the tumor necrosis factor-alpha (TNFalpha)-induced expression of ICAM-1 and VCAM-1 by monolayers of human endothelial cells… CONTINUE READING

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