ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.

@article{Liu2012ICAM1activatedSA,
  title={ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.},
  author={Guoquan Liu and Aaron T Place and Zhenlong Chen and Viktor M Brovkovych and Stephen M. Vogel and William A Muller and Randal A. Skidgel and Asrar B. Malik and Richard D Minshall},
  journal={Blood},
  year={2012},
  volume={120 9},
  pages={1942-52}
}
Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signaling contributes to PMN transmigration mediated by PECAM-1. We tested this concept and the roles of endothelial nitric oxide synthase (eNOS) and Src activated by PMN ligation of… CONTINUE READING
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