ICAM-1 Targeted Nanogels Loaded with Dexamethasone Alleviate Pulmonary Inflammation

  title={ICAM-1 Targeted Nanogels Loaded with Dexamethasone Alleviate Pulmonary Inflammation},
  author={M. Carme Coll Ferrer and Vladimir V. Shuvaev and Blaine Zern and Russell J Composto and Vladimir R Muzykantov and David M. Eckmann},
  booktitle={PloS one},
Lysozyme dextran nanogels (NG) have great potential in vitro as a drug delivery platform, combining simple chemistry with rapid uptake and cargo release in target cells with "stealth" properties and low toxicity. In this work, we study for the first time the potential of targeted NG as a drug delivery platform in vivo to alleviate acute pulmonary inflammation in animal model of LPS-induced lung injury. NG are targeted to the endothelium via conjugation with an antibody (Ab) directed to… CONTINUE READING
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