ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes

@inproceedings{Yanguas2018ICAM1LFA1DC,
  title={ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes},
  author={A. Ibiricu Yanguas and Saray Garasa and {\'A}lvaro Teijeira and Cristina Aub{\'a} and Ignacio Melero and Ana Rouzaut},
  booktitle={Front. Immunol.},
  year={2018}
}
The quantity of T-lymphocytes reaching the draining lymph nodes from tumors is likely important to mount effective distant responses and for the establishment of long term systemic memory. Looking into mechanisms behind lymphocyte egress, we directed our attention to leukocyte adhesion mechanisms inside tumors. Here we demonstrate that activated T-cells form intra-tumor aggregates in a LFA-1-ICAM-1-dependent fashion in mouse models of melanoma and breast cancer. We also provide evidence of the… CONTINUE READING

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