ICAM-1: isoforms and phenotypes.

  title={ICAM-1: isoforms and phenotypes.},
  author={Theresa N. Ramos and Daniel C. Bullard and Scott Robert Barnum},
  journal={Journal of immunology},
  volume={192 10},
ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses. The function and expression of these isoforms on various cell types are poorly understood. In the generation of ICAM-1-deficient mice, two isoform-deficient ICAM-1 mutants… CONTINUE READING

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