IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending.

@article{Hendrickson2004IC138IA,
  title={IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending.},
  author={Triscia W. Hendrickson and Catherine A. Perrone and Paul Griffin and Kristin Wuichet and Joshua Mueller and Pinfen Yang and Mary E Porter and Winfield S Sale},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 12},
  pages={
          5431-42
        }
}
Increased phosphorylation of dynein IC IC138 correlates with decreases in flagellar microtubule sliding and phototaxis defects. To test the hypothesis that regulation of IC138 phosphorylation controls flagellar bending, we cloned the IC138 gene. IC138 encodes a novel protein with a calculated mass of 111 kDa and is predicted to form seven WD-repeats at the C terminus. IC138 maps near the BOP5 locus, and bop5-1 contains a point mutation resulting in a truncated IC138 lacking the C terminus… CONTINUE READING

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The light chains of Chlamydomonas flagellar dyneins interact with components required for both motor assembly and regulation

  • L. M. DiBella, M. Skatato, R. S. Patel-King, G. J. Pazour, S. M. King
  • Mol. Biol. Cell
  • 2004
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