IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility.

Abstract

To understand the mechanisms that regulate the assembly and activity of flagellar dyneins, we focused on the I1 inner arm dynein (dynein f) and a null allele, bop5-2, defective in the gene encoding the IC138 phosphoprotein subunit. I1 dynein assembles in bop5-2 axonemes but lacks at least four subunits: IC138, IC97, LC7b, and flagellar-associated protein… (More)
DOI: 10.1091/mbc.E09-04-0277

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