IBS: Lubiprostone: trials and tribulations

  title={IBS: Lubiprostone: trials and tribulations},
  author={Michael D Crowell},
  journal={Nature Reviews Gastroenterology &Hepatology},
the selective, chloride channel 2 activator, lubiprostone, facilitates intestinal-fluid secretion and stimulates gastrointestinal motility. these effects increase stool frequency and improve abdominal discomfort for patients with constipation-predominant IBs, which makes lubiprostone the newest addition to the treatment armamentarium for these patients. Findings from a new, pivotal, phase III study by Drossman and colleagues support the use of lubiprostone in such patients. 
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