IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

@article{Benard2010IBRDC2AI,
  title={IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.},
  author={Giovanni Benard and Albert Neutzner and Guihong Peng and Chunxin Wang and Ferenc Liv{\'a}k and Richard J Youle and Mariusz Karbowski},
  journal={The EMBO journal},
  year={2010},
  volume={29 8},
  pages={1458-71}
}
Bax, a pro-apoptotic protein from the Bcl-2 family, is central to apoptosis regulation. To suppress spontaneous apoptosis, Bax must be under stringent control that may include regulation of Bax conformation and expression levels. We report that IBRDC2, an IBR-type RING-finger E3 ubiquitin ligase, regulates the levels of Bax and protects cells from unprompted Bax activation and cell death. Downregulation of IBRDC2 induces increased cellular levels and accumulation of the active form of Bax. The… CONTINUE READING