IBD: Visilizumab not useful for intravenous steroid-refractory ulcerative colitis

  title={IBD: Visilizumab not useful for intravenous steroid-refractory ulcerative colitis},
  author={Natalie J. Wood},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  • Natalie J. Wood
  • Published 6 January 2011
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
the potential of t-cell based therapies for severe ulcerative colitis has been called into question by the findings of an international, multicenter study. two open-label trials had indicated that visilizumab—a monoclonal antibody to the t-cell receptor CD3—was efficacious for intravenous corticosteroid-refractory ulcerative colitis. william sandborn and colleagues therefore conducted a 90-day randomized, double-blind, placebocontrolled trial of visilizumab in this patient population at a dose… 

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Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis

Visilizumab at a dose of 5 μg/kg for two consecutive days was not effective for severe, corticosteroid-refractory UC and was associated with increased cardiac and vascular adverse events.