IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo

@article{Perrelet2002IAPsAE,
  title={IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo},
  author={Daniel Perrelet and Anna Ferri and Peter Liston and Patrick Muzzin and R. G. Korneluk and Ann C. Kato},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={175-179}
}
During embryonic development, and in certain neurodegenerative diseases, neurons die by apoptosis. A new family of anti-apoptotic proteins, termed inhibitors of apoptosis (IAP), suppresses apoptosis through the direct inhibition of caspases. The anti-apoptotic activity of IAPs is inhibited by second mitochondria-derived activator of caspase (Smac)/DIABLO and XAF1 (ref. 8). IAPs, as well as neurotrophic factors, can protect degenerating neurons both in vivo and in vitro. However, the downstream… CONTINUE READING

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ACKNOWLEDGEMENTS This work was supported by the Association Française contre les Myopathies

  • Verhagen, M A.
  • Cell 102,
  • 2000

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