IAP antagonists induce anti-tumor immunity in multiple myeloma

  title={IAP antagonists induce anti-tumor immunity in multiple myeloma},
  author={Marta Chesi and Noweeda N Mirza and Victoria M Garbitt and Meaghen E Sharik and Amylou C Dueck and Yan W. Asmann and Ilseyar Akhmetzyanova and Heidi E. Kosiorek and Arianna Calcinotto and Daniel L. Riggs and Niamh Keane and Gregory J. Ahmann and Kevin M Morrison and Rafael Fonseca and Martha Q. Lacy and David Dingli and Shaji K Kumar and Sikander Ailawadhi and Angela Dispenzieri and Francis K Buadi and Morie A Gertz and Craig B. Reeder and Yi Lin and Asher Alban Chanan-Khan and Alexander Stewart and David Robert Fooksman and P Leif Bergsagel},
  journal={Nature Medicine},
The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been identified in multiple malignancies as being potential therapeutic targets as a result of their role in the evasion of apoptosis. Consequently, small-molecule IAP antagonists, such as LCL161, have entered clinical trials for their ability to induce tumor necrosis factor (TNF)-mediated apoptosis of cancer cells. However, cIAP1 and cIAP2 are recurrently homozygously deleted in multiple myeloma… CONTINUE READING
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