IA-2 modulates dopamine secretion in PC12 cells.

@article{Nishimura2010IA2MD,
  title={IA-2 modulates dopamine secretion in PC12 cells.},
  author={Takuya Nishimura and Shin-Ichi Harashima and Hu Yafang and Abner Louis Notkins},
  journal={Molecular and cellular endocrinology},
  year={2010},
  volume={315 1-2},
  pages={81-6}
}
The secretion of the hormone insulin from beta cells is modulated by the expression of the dense core vesicle transmembrane protein IA-2. Since IA-2 is found in neuroendocrine cells throughout the body, the present experiments were initiated to determine whether the expression of IA-2 also modulates the secretion of neurotransmitters. Using the dopamine-secreting pheochromocytoma cell line PC12, we found that the overexpressions of IA-2 increased the cellular content and secretion of dopamine… CONTINUE READING

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