IA-2 is not required for the development of diabetes in NOD mice

Abstract

diabetes have autoantibodies to IA-2 and/or GAD65 and these autoantibodies have become important predictive markers [9]. Thus, there are major differences between the NOD mouse model and the human disease. Although IA-2 is not involved in the diabetes of NOD mice, the extent to which the autoimmune response to IA-2 may contribute to the pathogenesis of Type 1 diabetes in humans has yet to be solved.

DOI: 10.1007/s00125-003-1252-z

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@article{Kubosaki2003IA2IN, title={IA-2 is not required for the development of diabetes in NOD mice}, author={Atsutaka Kubosaki and Junnosuke Miura and Abner Louis Notkins}, journal={Diabetologia}, year={2003}, volume={47}, pages={149-150} }