IA-2 combined epitope assay: a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes.

@article{Tiberti2005IA2CE,
  title={IA-2 combined epitope assay: a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes.},
  author={Claudio Tiberti and Antonella Verrienti and Benedetta Fiore and Liping Yu and George S. Eisenbarth and Francesco Dotta and Umberto di Mario},
  journal={Clinical immunology},
  year={2005},
  volume={115 3},
  pages={260-7}
}
Islet tyrosine phosphatase 2 (IA-2) is one of the major autoantigens in type 1 diabetes. The aim of this work was to evaluate which IA-2 construct(s) among those usually employed has the highest sensitivity and specificity for detecting IA-2 autoantibodies in autoimmune diabetes and whether the combination of different IA-2 constructs into a single assay allows the detection of immunoreactivities otherwise not detectable by a single construct. For this purpose, we tested the single… CONTINUE READING
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