IA-2 autoantibodies predict impending Type I diabetes in siblings of patients

@article{Decochez2002IA2AP,
  title={IA-2 autoantibodies predict impending Type I diabetes in siblings of patients},
  author={K. Decochez and I. De Leeuw and B. Keymeulen and C. Mathieu and R. Rottiers and I. Weets and E. Vandemeulebroucke and I. Truyen and L. Kaufman and F. Schuit and D. Pipeleers and F. Gorus},
  journal={Diabetologia},
  year={2002},
  volume={45},
  pages={1658-1666}
}
Abstract Aims/hypothesis. Multiple islet autoantibody positivity is currently believed to best predict progression to Type I (insulin-dependent) diabetes mellitus. We compared its predictive value with that of positivity for a particular type of islet autoantibody, directed against the IA-2 antigen. Methods. Autoantibodies against islet cell cytoplasm (ICA), insulin (IAA), GAD (GADA) and IA-2 (IA-2A) were measured at initial sampling in 1724 non-diabetic siblings (median age [range]:16 [0–39… CONTINUE READING
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