I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones.

Abstract

An efficient and applicable I2-catalyzed intramolecular dehydrogenative C-O/C-N coupling reaction via activating the C-H bond adjacent to the N atom has been developed to provide dozens of substituted benzoxazinones (31 examples) and quinazolinones (5 examples) in good to excellent yields (up to 98%). This one-pot methodology has significant advantages… (More)
DOI: 10.1039/c7ob02038d