I.v. clonidine: does it work as a hypotensive agent with inhalation anaesthesia?

@article{Lee1999IvCD,
  title={I.v. clonidine: does it work as a hypotensive agent with inhalation anaesthesia?},
  author={Jeong Jun Lee and Anthony Timothy Lovell and Michelle Parry and Hilary R. Glaisyer and Lesley M Bromley},
  journal={British journal of anaesthesia},
  year={1999},
  volume={82 4},
  pages={639-40}
}
In a double-blind, randomized, placebo-controlled study, 41 patients received clonidine 3 micrograms kg-1 or placebo at induction of isoflurane and nitrous oxide in oxygen anaesthesia. Metoprolol was also given to achieve a systolic arterial pressure of 80 mm Hg. Requirements for metoprolol were significantly less in the clonidine group (P < 0.00035), with no significant difference in mean arterial pressures over time. It would appear that clonidine is an i.v. hypotensive agent worthy of… CONTINUE READING

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Therapeutic Role of Clonidine in Anesthesia during Laparoscopic Surgeries

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