I. The Study Program and Objectives

  title={I. The Study Program and Objectives},
  author={Lippincott Williams Wilkins},
  • L. Wilkins
  • Published 1 April 1970
  • Medicine
  • Circulation
AN EPIDEMIOLOGICAL approach to coronary heart disease (CHD) is suggested by the sheer magnitude of the problem, as measured by the number of persons affected and by the obvious fact that hope of controlling the disease can only come from preventive measures applicable to populations or population segments. The urgency of finding means of prevention is sharpest for men in middle age for it is in that group that the social cost of CHD is greatest. Figure I. 1 shows the dominance of CHD as a cause… 
13 Citations
When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project
Evidence from two ongoing population-based, prospective studies conducted in Finland supports that the ability to prevent or delay the risk of premature atherosclerosis and its clinical sequelae later in life lies in maintaining a low lifetime risk by preventing the development of risk factors in early life.
Long-term predictors of survival for the Seven Countries Study cohort from Crete: from 1960 to 2000.
Analysis of 25-year mortality data from the 16 cohorts of participants indicated that the cohort from Crete had the lowest age-standardised all-cause and coronary heart disease death rates, and the Cretan cohort displays favourable 40-year survival.
Associations between classical cardiovascular risk factors and coronary artery disease in two countries at contrasting risk for myocardial infarction: the PRIME study.
It is concluded that the higher prevalence of CAD in Northern Ireland cannot be explained by major differences in the susceptibility to classical risk factors; the difference in risk appears mainly related in NorthernIreland to other risk factors including a worse lipid profile and genetic/environmental interactions.
Major and minor electrocardiographic abnormalities and risk of death from coronary heart disease, cardiovascular diseases and all causes in men and women.
The results indicate the independent association between ECG abnormalities and mortality from coronary heart disease, all cardiovascular diseases and all causes, with greater relative significance in middle-aged United States men than women.
Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis
Dietary recommendations were introduced for 220 million US and 56 million UK citizens by 1983, in the absence of supporting evidence from RCTs, with no differences in all-cause mortality and non-significant differences in CHD mortality, resulting from the dietary interventions.
Development of new coronary atherosclerotic lesions during a 4-year multifactor risk reduction program: the Stanford Coronary Risk Intervention Project (SCRIP).
These data indicate that intensive multifactor risk reduction tends to diminish the frequency of new coronary lesion formation.
Prevention of heart disease.
Programs should aim for control of high-risk factors early in life, and the disease that underlies the coronary attack of middle age begins in childhood.
Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease.
Stepwise discriminant analysis indicates that smoking, hypertension, decreased apolipoprotein A-I, increased apoliprotein B, increased Lp(a) and diabetes are all significant factors in descending order of importance in distinguishing patients with coronary artery disease from normal control subjects.
Progression of coronary atherosclerosis: is coronary spasm related to progression?
A positive response to the ergonovine provocation test was the strongest factor for occurrence of both new myocardial infarction and progression without infarce, and multiple regression analysis selected three independent predictors of the occurrence of new my cardiac infarctions.
How the Precious Role of Wine in Mediterranean Diet Is Mediated by the Gastrointestinal Tract
It is demonstrated that wine intake has a beneficial effect on all-cause mortality that is additive to that of alcohol, and the role of wine in protecting the metabolic diseases is still unclear, but there are indications that even there the effects may be important.