I-region Genes Are Expressed on T and B Lymphocytes

  title={I-region Genes Are Expressed on T and B Lymphocytes},
  author={Peter Lonai and Hugh O Mcdevitt},
  journal={The Journal of Experimental Medicine},
  pages={1317 - 1323}
Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T… CONTINUE READING