I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.


Covering: 1950s to 2015During the 1950s, sheep ranchers in the western United States experienced episodic outbreaks of cyclopic lambs. In this highlight I describe how these mysterious incidents were traced to the grazing of Veratrum californicum wildflowers by pregnant ewes, leading to the discovery of cyclopamine () as a plant-derived teratogen. The… (More)
DOI: 10.1039/c5np00153f


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