I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family

@article{Chen1996ImfAN,
  title={I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family},
  author={C.-M.Amy Chen and Norbert Kraut and Mark Groudine and Harold Weintraub},
  journal={Cell},
  year={1996},
  volume={86},
  pages={731-741}
}
During embryogenesis, cells from the ventral and dorsal parts of the somites give rise to sclerotome and dermomyotome, respectively. Dermomyotome contains skeletal muscle precursors that are determined by the MyoD family of myogenic factors. We have isolated a novel myogenic repressor, I-mf (Inhibitor of MyoD family), which is highly expressed in the sclerotome. In contrast, MyoD family members are concentrated in the dermomyotome. We demonstrate that I-mf inhibits the transactivation activity… CONTINUE READING