I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family

@article{Chen1996ImfAN,
  title={I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family},
  author={C. Chen and N. Kraut and M. Groudine and H. Weintraub},
  journal={Cell},
  year={1996},
  volume={86},
  pages={731-741}
}
During embryogenesis, cells from the ventral and dorsal parts of the somites give rise to sclerotome and dermomyotome, respectively. Dermomyotome contains skeletal muscle precursors that are determined by the MyoD family of myogenic factors. We have isolated a novel myogenic repressor, I-mf (Inhibitor of MyoD family), which is highly expressed in the sclerotome. In contrast, MyoD family members are concentrated in the dermomyotome. We demonstrate that I-mf inhibits the transactivation activity… Expand
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  • W. Pan, Yingying Jia, +6 authors Lin Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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