I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.

@article{Carlson2003IKB,
  title={I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.},
  author={Deborah Carlson and David K. White and David L. Maass and Robin C Nguyen and Brett P. Giroir and J. Wright Horton},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 3},
  pages={H804-14}
}
This study examined the effects of either IkappaBalpha overexpression (transgenic mice) or N-acetyl-leucinyl-leucinyl-norleucinal (ALLN) administration (proteosome inhibitor in wild-type mice) on cardiomyocyte secretion of tumor necrosis factor-alpha (TNF-alpha) and on cardiac performance after burn trauma. Transgenic mice were divided into four experimental groups. IkappaBalpha overexpressing mice were given a third-degree scald burn over 40% of the total body surface area or wild-type… CONTINUE READING

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