(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.

Abstract

The primary cause of Alzheimer's disease is unlikely to be the much studied markers amyloid beta or tau. Their widespread distribution throughout the brain does not account for the specific identity and deep subcortical location of the primarily vulnerable neurons. Moreover an unusual and intriguing feature of these neurons is that, despite their diverse… (More)
DOI: 10.1016/j.neuropharm.2016.02.006

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Cite this paper

@article{GarciaRats2016IPP, title={(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.}, author={Sara Garcia-Rat{\'e}s and Paul Morrill and Henry Tu and Gwenael Pottiez and A M Badin and Cristina Tormo-Garcia and Catherine Heffner and Clive W. Coen and Susan A. Greenfield}, journal={Neuropharmacology}, year={2016}, volume={105}, pages={487-499} }