I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.

@article{Mcduffie1992IEindependentDO,
  title={I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.},
  author={Marcia Mcduffie and D. Schweiger and Barbara Reitz and Alina Ostrowska and Andrew M. Knight and Paul J Dyson},
  journal={Journal of immunology},
  year={1992},
  volume={148 7},
  pages={2097-102}
}
Analysis of TCR beta-chain V region (V beta) frequency among NOD lymphocytes reveals a profound depletion of V beta 3+ T cells, and a recent study has linked this phenomenon to the Mtv-3 insertion on chromosome 11. When the V beta 17a gene segment is introduced into mice with an nonobese diabetic mouse background, T cells bearing the TCR encoded by this gene segment are also dramatically reduced in frequency. Deletion of V beta 17a+ T cells segregates with deletion of T cells bearing V beta 3… CONTINUE READING