• Published 2015

I 2020 T mutant LRRK 2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT / GSK-3 β signaling pathway

@inproceedings{Ohta2015I2T,
  title={I 2020 T mutant LRRK 2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT / GSK-3 β signaling pathway},
  author={Etsuro Ohta and Tomoko Nihira and Akiko Uchino and Yoichi Imaizumi and Yohei Okada and Wado Akamatsu and Kayoko Takahashi and Hideki Hayakawa and Makiko Nagai and Manabu Ohyama and Masafuchi Ryo and Mieko Ogino and Shigeo Murayama and Akihiko Takashima and Kazutoshi Nishiyama and Yoshikuni Mizuno and Hideki Mochizuki and Fumiya Obata and Hideyuki Okano},
  year={2015}
}
Leucine-rich repeat kinase 2 (LRRK2) is the causative molecule of the autosomal dominant hereditary form of Parkinson’s disease (PD), PARK8, which was originally defined in a study of a Japanese family (the Sagamihara family) harboring the I2020T mutation in the kinase domain. Although a number of reported studies have focused on cell deathmediated bymutant LRRK2, details of the pathogenetic effect of LRRK2 still remain to be elucidated. In the present study, to elucidate the mechanism of… CONTINUE READING

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