IκB kinase regulation of the TPL-2/ERK MAPK pathway.

  title={IκB kinase regulation of the TPL-2/ERK MAPK pathway.},
  author={Thorsten Gantke and Srividya Sriskantharajah and Michael I. Sadowski and Steven C. Ley},
  journal={Immunological reviews},
  volume={246 1},
Nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) activation play central roles in the induction of gene expression in innate immune cells following pathogen recognition. TPL-2 (tumor progression locus 2) is the MAP 3-kinase component of an ERK-1/2 (extracellular signal-regulated kinase 1/2) MAPK pathway activated by Toll-like receptor and tumor necrosis factor receptor family stimulation. In this review, we discuss results obtained from our laboratory and others that show… CONTINUE READING
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