IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats.

@article{Orita2013IBK,
  title={IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats.},
  author={Sumihisa Orita and Masayuki Miyagi and Sayako Kobori and Takefumi Gemba and Tetsuhiro Ishikawa and Gen Inoue and Tomoaki Toyone and Yasuchika Aoki and Yawara Eguchi and Kazuhisa Takahashi and Seiji Ohtori},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2013},
  volume={13 3},
  pages={284-8}
}
BACKGROUND CONTEXT Nuclear factor-κB (NF-κB) is an essential gene transcriptional regulator of inflammatory cytokines, and it plays important roles in numerous conditions, including inflammatory and neuropathic pain, especially when discogenic pain is involved. Phosphorylation of IκB protein through IκB kinase (IKK) is the first step in the activation of NF-κB activation and the upregulation of NF-κB-responsive genes. PURPOSE To investigate whether IKK inhibition alters the properties of pain… CONTINUE READING

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