I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.

@article{Ohta2009I2020TLR,
  title={I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.},
  author={Etsuro Ohta and Yuri Katayama and Fumitaka Kawakami and Matsuri Yamamoto and Kana Tajima and Tatsunori Maekawa and Naoyuki Iida and Seisuke Hattori and Fumiya Obata},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={390 3},
  pages={710-5}
}
Leucine-rich repeat kinase 2 (LRRK2) has been identified as the causal gene for autosomal dominant familial Parkinson's disease (PD), although the mechanism of neurodegeneration involving the mutant LRRK2 molecules remains unknown. In the present study, we found that the protein level of transfected I(2020)T mutant LRRK2 was significantly lower than that of wild-type and G(2019)S mutant LRRK2, although the intracellular localization of the I(2020)T and wild-type molecules did not differ. Pulse… CONTINUE READING
12 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

A

  • E. Greggio, S. Jain, A. Kingsbury, R. Bandopadhyay, P. Lewis
  • Kaganovich, M.P. van der Brug, A. Beilina, J…
  • 2006
Highly Influential
4 Excerpts

E

  • C. J. Gloeckner, N. Kinkl, A. Schumacher, R. J. Braun
  • O’Neill, T. Meitinger, W. Kolch, H. Prokisch, M…
  • 2006
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…