Hysteretic and graded responses in bacterial two-component signal transduction.

@article{Igoshin2008HystereticAG,
  title={Hysteretic and graded responses in bacterial two-component signal transduction.},
  author={Oleg A. Igoshin and Rui Alves and Michael A. Savageau},
  journal={Molecular microbiology},
  year={2008},
  volume={68 5},
  pages={1196-215}
}
Bacterial two-component systems (TCS) are key signal transduction networks regulating global responses to environmental change. Environmental signals may modulate the phosphorylation state of sensor kinases (SK). The phosphorylated SK transfers the phosphate to its cognate response regulator (RR), which causes physiological response to the signal. Frequently, the SK is bifunctional and, when unphosphorylated, it is also capable of dephosphorylating the RR. The phosphatase activity may also be… CONTINUE READING

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