Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.

  title={Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.},
  author={Wei Sha and Jonathan R Moore and Katherine Chen and Antonio D Lassaletta and Chung-Seon Yi and John J. Tyson and Jill C. Sible},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 3},
Cells progressing through the cell cycle must commit irreversibly to mitosis without slipping back to interphase before properly segregating their chromosomes. A mathematical model of cell-cycle progression in cell-free egg extracts from frog predicts that irreversible transitions into and out of mitosis are driven by hysteresis in the molecular control system. Hysteresis refers to toggle-like switching behavior in a dynamical system. In the mathematical model, the toggle switch is created by… CONTINUE READING
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