Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.

@article{Sha2003HysteresisDC,
  title={Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.},
  author={Wei Sha and Jonathan R Moore and Katherine Chen and Antonio D Lassaletta and Chung-Seon Yi and John J. Tyson and Jill C. Sible},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 3},
  pages={975-80}
}
Cells progressing through the cell cycle must commit irreversibly to mitosis without slipping back to interphase before properly segregating their chromosomes. A mathematical model of cell-cycle progression in cell-free egg extracts from frog predicts that irreversible transitions into and out of mitosis are driven by hysteresis in the molecular control system. Hysteresis refers to toggle-like switching behavior in a dynamical system. In the mathematical model, the toggle switch is created by… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 218 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 15 references

Chaos

  • J E Ferrell, Jr, W Xiong
  • Chaos
  • 2001

J. Theor. Biol

  • J J Tyson, B Novak
  • J. Theor. Biol
  • 2001

Mol. Biol. Cell

  • J Lee, A Kumagai, W G Dunphy
  • Mol. Biol. Cell
  • 2001

Dev. Biol

  • S Kim, C Li, J Maller
  • Dev. Biol
  • 1999

Proc. Natl. Acad. Sci. USA 96

  • B Aguda
  • Proc. Natl. Acad. Sci. USA 96
  • 1999

Biophys. Chem

  • G Marlovits
  • Biophys. Chem
  • 1998

J. Cell Biol

  • A Kumagai, Z Guo, K H Emami, S X Wang, W G Dunphy
  • J. Cell Biol
  • 1998

Science

  • J E Ferrell, Jr, E M Machleder
  • Science
  • 1998

Trends Biochem. Sci

  • J J Tyson, B Novak, G M Odell, K Chen, C D Thron
  • Trends Biochem. Sci
  • 1996

J. Cell Sci

  • B Novak, J J Tyson
  • J. Cell Sci
  • 1993

Similar Papers

Loading similar papers…