Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels.

@article{Thorne2002HypoxicVI,
  title={Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels.},
  author={George D. Thorne and Laura Conforti and Richard J. Paul},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 1},
  pages={H247-53}
}
We (Thorne GD, Shimizu S, and Paul RJ. Am J Physiol Cell Physiol 281: C24-C32, 2001) have recently shown that organ culture for 24 h specifically inhibits relaxation to acute hypoxia (95% N(2)-5% CO(2)) in the porcine coronary artery. Here we show similar results in the porcine carotid artery and the rat and mouse aorta. In the coronary artery, part of the inability to relax to hypoxia after organ culture is associated with a concomitant loss in ability to reduce intracellular Ca(2… CONTINUE READING

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Effects of hypoxia on isometric force, intracellular Ca2 , pH, and energetics in porcine coronary artery

  • S Shimizu, PS Bowman, Thorne G 3rd, RJ Paul
  • Circ Res
  • 2000
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