Hypoxic tolerance enhanced by beta-hydroxybutyrate-glucagon in the mouse.

  title={Hypoxic tolerance enhanced by beta-hydroxybutyrate-glucagon in the mouse.},
  author={Steven Eiger and Jeffrey R. Kirsch and L G D'alecy},
  volume={11 5},
A coorelation has been observed between increased blood ketones and the tolerance of mice to hypoxia (4-5% oxygen). In previous studies fasted mice, alloxan diabetic mice and mice given 1,3-butanediol were found to be ketotic and to have increased tolerance to hypoxia. We attempted to induce a similar increased hypoxic tolerance by direct elevation of blood ketones with IV and IP beta-hydroxybutyrate (BHB). No increase in hypoxic tolerance was observed with BHB alone. Inasmuch as fasting and… CONTINUE READING
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