Hypoxic stress stably alters apoptotic parameters on U937 cells.


Tumor promonocytic U937 cells cultured under a low O(2)/high CO(2) atmosphere display altered characteristics after restoration of normal atmosphere: increased resistance to apoptosis induced by different treatments; apoptotic morphology; lack of glutathione (GSH) extrusion in apoptosis; lack of protection by antioxidants; and lack of Ca(2+) mobilization with thapsigargin. These alterations were stably maintained for many months of culture in normal conditions, originating the stable U937-HX variant. Since the hypoxic treatment did not produce a great selective pressure, the alterations are conceivably the result of stable adaptative response.

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@article{Nicola2003HypoxicSS, title={Hypoxic stress stably alters apoptotic parameters on U937 cells.}, author={Milena De Nicola and Francesca Liuzzi and C Cerella and Maria Clara D'Alessio and Antonio Bergamaschi and Andrea Magrini and Lina Ghibelli}, journal={Annals of the New York Academy of Sciences}, year={2003}, volume={1010}, pages={426-9} }